Revised 8/2025

MDL 265 - Advance Clinical Chemistry (2 CR.)

Course Description

Presents principles of current special chemistry techniques. Lecture 2 hours per week.

General Course Purpose

The purpose of this course is to prepare students with the knowledge of body chemistry analysis procedures   within a clinical chemistry laboratory and the correlation to various disease states. It is designed to produce entry level competence needed to perform at the level of a medical laboratory technician in a sophisticated clinical chemistry laboratory.

Course Prerequisites/Corequisites

Students should be enrolled in the first year of the Medical Laboratory Technology AAS degree program or receive program director approval.

Students enrolling in this course are expected to be familiar with basic general chemistry and the principles of human anatomy and physiology. They should have completed CHM 111 and BIO 141 and with a grade of “C” or better. Completion of the first year fall semester core courses with a grade of “C” or better is required. These courses are MDL 101, MDL 140, MDL 125.

Course Objectives

  • List the clinically significant carbohydrates and discuss diabetes management
  • Discuss the analytes measured in the diagnosis and management of kidney disease
  • Correlate increases in enzyme activity, proteins, non-protein nitrogens and bilirubin with disease processes in liver, pancreas, muscle, and other tissues and
  • Define cardiac markers and relate to the diagnosis of myocardial infarction (MI).
  • Discuss lipid profiles and how they are utilized in minimizing cardiovascular
  • List the physical and chemical properties of clinical measured hormones.
  • Discuss the metabolism, action, and measurement of vitamins.
  • Describe the pharmacokinetics and disease state correlation of therapeutic drugs.
  • List the physical and chemical properties of clinically measured toxins.

Major Topics to Be Included

  • Diabetes and Other Carbohydrate Disorders
  • Assessment of Renal Function
  • Assessment of Liver Function
  • Assessment of Cardiovascular Disorders
  • Assessment of Nutrition and Digestive Function
  • Endocrine Disorders and Function
  • Reproductive Endocrinology and Fetal Testing
  • Therapeutic Drug Monitoring and Toxicology
  •  Immunoassays